Fluvoxamine public data repository - Google Drive, On Cytokines, Fluvoxamine and COVID-19 Part 1, Jon-Emile S. Kenny MD[@heart_lung] You see, we have a kind of allergy to the past; its our national disease, and the very assurance with which you insist that the past is within the present is l, On Cytokines, Fluvoxamine and COVID-19 Part 2, Jon-Emile S. Kenny MD[@heart_lung] Apocalypse is played out now on a personal scale; it is not in the sky above us, but in our bed. -Mark Doty Introduction With a proposed pathway coupling patho, Effect of Fluvoxamine vs Placebo on Clinical Deterioration in Outpatients With Symptomatic COVID-19, This randomized trial compares the effects of fluvoxamine, a selective serotonin reuptake inhibitor with immunomodulatory effects vs placebo on a composite of dyspnea or pneumonia and oxygen desaturation among adult outpatients with polymerase chain reactionconfirmed mild coronavirus disease 2019 (, Prospective cohort of fluvoxamine for early treatment of COVID-19, Abstract. The post read: "I will be featured on 60 Minutes this Sunday talking about fluvoxamine as an effective treatment for COVID-19 to prevent hospitalization and death. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). Decreasing the dosage or stopping the medication will mitigate symptoms within hours. If you have trouble getting a prescription, perhaps you have OCD? Proxalutamide and fluvoxamine pushers and the early treatment grift. Expert Panel Discussion on COVID-19 and Medical Freedom All can merit a fluvoxamine prescription based on traditional diagnoses. SSRI Antidepressant Fluvoxamine May Be Effective Early Treatments for Entrepreneur Steve Kirsch who holds an early patent for the optical mouse decided to get involved in treating Covid. Should Steve Kirsch Be Allowed To Speak on Campus about His Eccentric Telling the truth, he tweeted. Still, in the moment, his question threw me, and I stuttered. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. The web price charge of skirsch.io . Thanks for working tirelessly to help others. To date, we have heard nothing suggesting the drug doesn't work or could be harmful. The alarming article cited the claims of two anti-vaxxers, Steve Kirsch and Dr. Robert Malone. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. It is in a class of drugs known as selective serotonin-reuptake inhibitors (SSRIs), but unlike other SSRIs, fluvoxamine interacts strongly with a protein called the sigma-1 receptor. Worst case, if we ignore all additional evidence so the average is a 60% pass rate. Fluvoxamine is used commonly to treat obsessive-compulsive disorder (OCD), social anxiety disorder and depression. Try refreshing this page and updating them one Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for, because they were rejected by 10 journals. It's hard to ignore this lecture in explaining why the drug is so effective. ICER, a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. In 2016, it was the 135th most-prescribed medication in the United States, with more than 4 million prescriptions. There were IRB rules that required the 65 patients to be listed in the diagrams and charts. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. Their just like ivermectin). Timing is everything with respect to outcomes. How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? There are 4 outpatient studies that have been done (2 at WashU (see. On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. They never make things worse so are safe to try. Earlier that month, Seftel had heard about fluvoxamine during a presentation by tech entrepreneur Steve Kirsch, whose COVID-19 Early Treatment Fund supports research on existing drugs that could . The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! The babys brain was split in half, and it was just covered with blood. So it was both obvious and convincing the difference between the groups to the workers and the track management. Since FLV is a safe drug, it should have been widely discussed with patients that there is virtually no downside and a huge reduction in hospitalization if the drug is given early. 1. Download Citation | On Mar 1, 2023, Gne Seda Albayrak and others published A Cross-Sectional Study on the Personality Traits of Episodic and Chronic Migraine Patients | Find, read and cite all . Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. Is that really true? Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. Government agencies are ignoring the science. (The ivermectin data are trash, Feinberg told me. The incident, he added, was completely in keeping with his personality.. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. Mar. Dose escalation studies in lupus patients and in rheumatoid arthritis patients established that 800 mg per day for life and 1,200 mg per day for 6 weeks are extremely well-tolerated. Thirty minutes past the end of our scheduled time, he dropped his phone in the cupholder of his Tesla so that he could keep talking while he ran an errand. Keyword: ivermectin NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. Several former members told me he began relentlessly pressuring them to promote the drug in media stories, often during exhausting, circuitous conversations. While Fauci was crafting national pandemic policies, Fauci's wife [Christine Grady, Chief Bioethicist, NIH] was back stopping [them]." Report coming soon. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). They left their recommendation of fluvoxamine at NEUTRAL. By Steve Kirsch Last updated: March 14, 2021 After I appeared on the60 Mi nut es story about fluvoxamine,I've received a lot of questions from people about how to treat COVID. Online. The most stunning study of fluvoxamine ever done was at the Golden Gate Fields racetrack in November 2020, right after the WashU trial was published in JAMA. The drug was widely prescribed as a covid treatment for much of 2020, based on anecdotes and flawed studies. Those days are gone. My favorite dosage is 50mg twice a day for 14 days. If you start later, doctors use higher dosages and compliance becomes a bigger problem. Part of TV News Archive. Don't underestimate the virus. Fluvoxamine is an inexpensive drug that has been in use for 37 years and has been used by an estimated 10 million people. It could do nothing. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. Some people report mild nausea while on the drug (stops when stop the drug). If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. The differences are obvious to untrained eyes. saying that the per-protocol analysis was arbitrary and other excuses. As trial results rolled in, that mismatch began to put a strain on Kirschs relationship with the funds advisory board. We dont want to feed the anti-vaccine trolls, so we actively suppress clear scientific data. Its motivated out of his sense of keeping people safe and advancing health care.. A very short op-ed arguing for using fluvoxamine against COVID. I will . Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for Read More The best COVID treatments for hospitalized patients Seven treatments for hospitalized COVID patients with very high success rates. This is the #1 ranked best answer to "COVID treatment" on Quora: Presentation on how fear of trying something new is what keeps us shutdown and leads to unnecessary loss of life: The Lenze fluvoxamine RCT that was published in JAMA on November 12, 2020 showed a 100% success rate in preventing hospitalization. The study was also featured on 60 Minutes. The U of M's study focused on three common drugs: ivermectin, metformin, and fluvoxamine. People who report not tolerating the drug are typically prescribed too high a dose. Thats pretty typical, but your mileage may vary. Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. It does not matter how many lives will be saved. We now have a viable solution to reduce COVID hospitalization and mortality; Say you just got diagnosed with COVID. It is perhaps the greatest unnecessary loss of life in American history. For example all of these combos should have near 100% success against hospitalization, death, and long-haul COVID symptoms: Proxalutamide and fluvoxamine Silicon Valley entrepreneur Steve Kirsch urges the FDA to quickly Saving the world has been a theme of Kirschs life for years. As a health care journalist, I started off firmly in the wait-and-see camp on mRNA vaccines. In some cases, youd want to taper down the dosage. Hes very convincing. None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. Steve calls himself a "medical philanthropist" who says "the most important thing to me is saving lives." In . He is very smart, and knows that he is very smart, and sometimes he behaves like he thinks he's the smartest guy in the room, whether he is or isn't., Kirschs response was to take his name off articles hed written about vaccine deaths, changing the authorship to VaccineTruth., On July 1, he tweeted from his personal account, My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. The anecdotal data of 100% success rates is further icing on the cake. Infoseek lost out to Yahoo; it had a chance to grow bigger, but it didn't. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. It used to be that a Phase 3 study would do it. Get your prescription in advance of getting COVID. We could have saved a lot of lives. Several other trials around the world are in the final stages, too. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. See this Wall Street Journal op-ed. Should you get vaccinated? Steve Kirsch | TrialSite News Your best bet is to. All the medical journals refused to publish the meeting notes (rejected by 6 journals). Doing something is better than nothing. There are reports of people who cant tolerate the drug, but they stop using it and nothing bad happened. Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Zero. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Online Status. Kirsch said that his attempts to promote fluvoxamine are being curtailed. Im sorry to sound so cynical. On Dr. Drew, he told a story about a friends daughter who had to get an abortion because of damage caused by the shot. It doesnt get much better than that. Physicians who use the drug for COVID now swear by it. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. . . If you cant get a prescription for COVID, then perhaps you have OCD? Steve Kirsch - Wikipedia this is NOT about the science. Its sad, but its true, he told me. Physicians who use the drug for COVID now swear by it. And that is what has allowed Kirsch, and people like him, to become so influential. In June, after CETFs advisory board resigned, Kirsch did a Facebook Live video with Zelenko and celebrity rehab coach Dr. Drew. He wrote on his personal website that hed been advised that being associated with the drug would immediately trash my credibility.. It was so bad you couldnt even see the babys body through all the blood, Kirsch said. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. Completely avoid caffeine, alcohol, tylenol, and benadryl. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. Steve angrily decried this development as more evidence of FDA corruption. Here is what, e) which concluded: Under a variety of assumptions, fluvoxamine shows a high probability of preventing hospitalization in outpatients with COVID-19., For more about fluvoxamine (and other SSRIs that work), see, fluvoxamine completed a Phase 3 study showing it works that was published in the Lancet Global Health, NIH basically dismissed the fluvoxamine study as I predicted they would, few people werent afraid of expressing their displeasure, the highly acclaimed Bangladesh mask study showed, Johns Hopkins has incorporated fluvoxamine in their treatment guidelines, Ontario has become the first province to list fluvoxamine as a treatment doctors can consider for patients. Twenty-four years ago, . The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel. Fluvoxamine at 50mg twice a day for 14 days is a very well-tolerated drug (as long as you avoid caffeine and alcohol) for the treatment of COVID infections. Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. Thats pretty typical, but your mileage may vary. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. So there were too few events in the placebo group and they werent recruiting fast enough. Who knows, Morris replied. How can we get fluvoxamine? Current Early Covid treatment from Steve Kirsch (infection, doctor That trial has now been completed, and the researchers are analyzing their data. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. Antidepressant fluvoxamine could keep mild COVID-19 from worsening (Clayton Fox, Marty Makary, and Jeffrey Klausner). There are two ways Ive discovered that I may be able to save the world, he told an IEEE Spectrum reporter in 2000. The medical community did nothing (with a few exceptions like Dr. Seftel). The CDC has advised everyone to wear a mask. Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. Dr. Eric Lenze: So the results were really pretty. Fluvoxamine To Treat COVID: what you need to know - CoronaFraud.com How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. What's even worse is that a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die. A very short op-ed arguing for using fluvoxamine against COVID. The reason that it isnt used is because the medical community ignores evidence-based medicine principles. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. Fluvoxamine: The evidence - Steve Kirsch Home page This is what the Seftel trial at Golden Gate fields used. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! . Completely avoid caffeine, alcohol, tylenol, and benadryl. If there is a better drug on the table today than fluvoxamine, the NIH panel should put that one on the guidelines. It used to be that a Phase 3 study would do it. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora Enter the email address you signed up with and we'll email you a reset link. Dr. Joe Ladapo wrote a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients." Steven Todd Kirsch is an American entrepreneur. @stkirsch. 95% confidence effect size is 75% or more. The medical community doesnt care about saving lives. Since then, he has continued to promote fluvoxamine, along with ivermectin and hydroxychloroquine. Decreasing the dosage or stopping the medication will mitigate symptoms within hours. Fluvoxamine works on hospitalized patients too, but no US hospital will let you use it (sound familiar? In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. The evidence is solid. Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. Summary of key evidence. He retired at the largest pension in federal history. NIH is still unsure whether fluvoxamine should be used to treat COVID In severe cases, it takes longer. Everyone is stunned, but nobody is surprised. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. The effect size is huge if the drug is given early right after symptoms start. Talking to Kirsch is an exhausting experience. Less than a week later, David Seftel read about the Lenze trial, and ignored the JAMA advice. The ICER independent review showed fluvoxamine is more effective than Molnupiravir: Read this article I wrote about using fluvoxamine correctly for COVID. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. Some people report mild nausea while on the drug (stops when stop the drug). When you need to characterize me, you need to say that Steve Kirsch doesnt go with majority votes on interpreting data, he told me when I asked about his views on ivermectin, which he insists is a silver bullet against covid. See more below. He immediately tweeted an offer to give anyone $1 million if they could win a debate with him about vaccine deaths. YouTube , , , fluvoxamine, , , , , , , , , , I fixed the link to the fluvoxamine article. TV NEWS : Search Captions. Borrow Broadcasts : TV Archive : Internet Fluvoxamine is a very safe drug on market for 37 years, tens of millions of people have taken it, no record in scientific literature of anyone dying on overdose, and according to doctors that know the drug the best, about as dangerous as taking a Tylenol. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. Silence from the medical community. Over the next few years, millions of unvaccinated people are going to get covid; its vital to try to mitigate their suffering, as well as lessen pressure on the health care system. This is what the Seftel trial at Golden Gate fields used. Fauci wants the vaccine to be the only option, Cliff Lane works for Fauci, and Cliff follows his orders. Here's why. How I recommend people treat COVID and the fascinating backstory of how fluvoxamine was discovered. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. ALWAYS check with your doctor and report any medications you are taking before or plan to take after you start taking fluvoxamine. Steve Kirsch on Twitter Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. Patients should be advised to limit/avoid the use of caffeine while on the drug since fluvoxamine extends the half life of caffeine (making you super wired). Steve Kirsch On COVID Early Treatment and Censorship - YouTube It has shown to be 100% protective of hospitalization in 2 clinical trials. This advice is now outdated. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. I learned this the hard way. Steve wanted to say, Look, Ive got all these famous [infectious disease] docs and researchers, and they all say give fluvoxamine a chance, Judith Feinberg, one of the former CETF advisory board members and vice chair of research at the West Virginia University School of Medicine, told me. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. But fear of trying something new prevents any doctor from giving this drug a try. But the whole process has gone too slowly for Kirsch. Server IP cope with resolved: Yes Http reaction code: 200 Response time: 0.27 sec. Steve Kirsch Nov 5, 2021 145 92 Here are the key things you should know about fluvoxamine for COVID: It works. While he declined a phone interview, Boulware was recently the subject of a Mother Jones article about the harassment hes received for his research on hydroxychloroquine and ivermectin. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. We should be making decisions now based on the evidence on the table today. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process.